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Exciting anti-aging  research has been taking place under the umbrella of TAME (Targeting Aging With Metformin), a six year long series of clinical studies conducted at 1t laboratories across the US . . . In addition to controlling diabetes, Metformin has shown great promise in helping to reverse the effect of aging.

Is there a diabetes medication out there that can reverse aging? 

Type 2 Diabetes is a condition in which blood sugar levels are dangerously elevated. It is often the result of obesity, lifestyle and genetic factors. This condition can lead to a number of serious health effects. It is, in fact, the seventh leading cause of death in the United States. In this article, we take a look at what causes diabetes and the warning signs. We’ll also identify what steps you can take to reverse the trends nd take a look at the latest research on Metformin, a diabetes medication which may help reverse aging. 

What Causes Diabetes?

Age – As we age the regenerative capacity of the pancreas slows down and it’s ability to make insulin declines. Despite the fact that an alarming number of people under 25 are developing the condition, most people who are diagnosed with Type-2 diabetes are aged between 55 and 60. (1)

* Family History – one in every three people with Type-2 diabetes has a close family member who also has the condition. 

* Race – We don’t quite know why, but people of certain ethnic origins, such as African Americans, Hispanics, American Indians and Asian-Americans, are more likely to develop Type-2 diabetes. 

* Pre-existing health conditions – High blood pressure, metabolic syndrome, impaired glucose tolerance along with heart disease and stroke all put you at higher risk of getting diabetes. 

* Viruses – Infections such as mumps, rubella, adenovirus, cytomegalovirus and coxsackievirus B can lead to the onset of Type-2 diabetes. 

* Bottle feeding – A number of recent studies have linked formula feeding with cow’s milk with Type-2 diabetes. Breastfeeding is highly recommended as is supplementing with vitamin D. 

* Liver or pancreatic disease – Any condition that impairs the ability of the pancreas and liver to do their job is going to make you more likely to become diabetic. 

There are some vital other factors that are major contributors to type-2 diabetes. These ones come under the category of lifestyle factors – they are things that we can control and make choices around. Here are the main avoidable risk factors: 

  • Obesity
  • Lack of exercise
  • Diet
  • Alcohol
  • Smoking

Warning Signs for Diabetes

There are a number of warning signs for diabetes. These include:

  • Uncommon thirst and appetite
  • Excessive urination
  • Weight gain or weight loss
  • Nausea
  • Irritation
  • Tingling of the extremities
  • Darkening of skin and possible skin infection

Pre-diabetes is a condition in which a person’s blood sugar levels are elevated. It is a precursor to diabetes. It is important for people who are at risk of developing diabetes to regularly have their blood sugar levels tested. 

The test that doctors use to assess blood sugar levels is called the A1C test. It is also known as the Haemoglobin A1C test and the HbA1C test. This test will provide you with an average of your blood glucose levels over the previous three months. (2)

The A1C test is a simple blood test that can be done in a doctor’s office or a lab. The following A1C test results provide a guideline as to your diabetes risk:

Normal: 5.7% or lower

Pre-Diabetes: 5.7-6.4%

Diabetes: 6.5% or higher

The key to preventing Type 2 Diabetes is to capture the trend in rising A1C levels before it gets into the pre-diabetes range. That requires getting a regular A1C test. If you are over the age of 45, we strongly recommend getting this done annually. 

Reversing the Diabetes Trend

Incorporating the following lifestyle habits into your routine will go a long way toward helping you manage your diabetes. 

  • Take a hot shower before going to bed: By doing so, you’ll be enhancing your circulation to such vital organs as the pancreas and kidneys. 
  • Exercise: Regular exercise, including strength training, will help to control blood sugar levels. It will even reduce the need for oral medications and insulin. (3)
  • Yoga: Many people have discovered that yoga, a mental, physical and spiritual discipline that originated in India more than 5,000 years ago, can do wonders in keeping diabetes in check while improving the diabetics overall quality of life.
  • Drink a daily detox liver cleanser every day.
  • Drink 10 8-ounce glasses of mineral water every day 
  • Eat a nutritious meals, consisting of lean proteins, fibrous and starchy carbs and healthy fats. (4)
  • Eliminate sugars from your diet –  use healthy substitutes such as Erythritol sweetener and stevia.
  • Get 8 hours sleep every night 

In conjunction with these positive steps, you should also remove the following from your life:

  • Sugar 
  • Alcohol 
  • Tobacco 
  • Red meat 
  • Artificial sweeteners 
  • MSG 
  • White flour, pasta and rice 
  • Instant and processed foods 
  • Canned foods 
  • Fruit and vegetable juices 

The TAME Trials: Can Metformin Reverse Aging?

Exciting anti-aging  research has been taking place under the umbrella of TAME (Targeting Aging With Metformin), a six year long series of clinical studies conducted at 1t laboratories across the US. The trials are led by AFAR Scientific Director Nir Barzilai, MD. 

The trial focuses on the ability of the FDA approved diabetes treatment drug Metformin. In addition to controlling diabetes, Metformin has shown great promise in helping to reverse the effect of aging. A number of studies have already shown that Netformin can significantly delay aging in animals. The TAME trials will determine whether Metformin has the ability to influence metabolic and cellular processes associated with the development of age-related conditions. 

This is the first major study to provide proof of concept that aging is a condition that can be reversed! (5)

Dr. David Sinclair is a world leader in the filed of anti aging research. He has done a lot of research regarding taking Metformin as an anti-aging hack. Dr. Sinclair, who is  professor of genetics, advocates taking 1 gram of Metformin per day, broken up into a morning and evening dosage of 0.5 grams. (6)

Research

  1. https://www.ncbi.nlm.nih.gov/books/NBK279339/
  2. https://www.cdc.gov/diabetes/managing/managing-blood-sugar/a1c.html#:~:text=A%20normal%20A1C%20level%20is%20below%205.7%25%2C%20a,your%20risk%20is%20for%20developing%20type%202%20diabetes.
  3. https://pubmed.ncbi.nlm.nih.gov/11570119/
  4. https://www.bmj.com/content/361/bmj.k2234
  5. https://www.afar.org/tame-trial#:~:text=Led%20by%20AFAR%20Scientific%20Director,disease%2C%20cancer%2C%20and%20dementia
  6. https://www.nextbigfuture.com/2019/02/anti-aging-researcher-david-sinclair-takes-metformin-nmn-nad-for-longevity.html

n the first three instalments of this series put forward a compelling case for a total paradigm shift when it comes to again. By transform our approach from sick care to preventative healthcare, we may be able to realize more life in out years as we grow older. In this final instalment, we focus in on the potential health spanning effects of regenerative medicine.